View Full Version : Molecular Cytogenetic analysis in Human and other Mammalia (including Rhodentia)

Sep 13, 10, 12:36
We are doing any kind of metaphase and interphase related molecular cytogenetic analysis in Human and other Mammalia (including Rhodentia).
For that we have home made probes (see Pubmed and search for Liehr T and FISH probes) and also a large collection of BAC-probes to characterizes and chromosome of interest.
We also do 3D-studies in cell nuclei.

Please see also our homepage

some papers are

Weise A, Gross M, Hinreiner S, Witthuhn V, Mkrtchyan H, Liehr T. POD-FISH: a new technique for parental origin determination based on copy number variation polymorphism. Methods Mol Biol. 2010;659:291-8.
Manvelyan M, Kempf P, Weise A, Mrasek K, Heller A, Lier A, Höffken K, Fricke HJ, Sayer HG, Liehr T, Mkrtchyan H. Preferred co-localization of chromosome 8 and 21 in myeloid bone marrow cells detected by three dimensional molecular cytogenetics. Int J Mol Med. 2009 Sep;24(3):335-41.
Weise A, Mrasek K, Fickelscher I, Claussen U, Cheung SW, Cai WW, Liehr T, Kosyakova N. Molecular definition of high-resolution multicolor banding probes: first within the human DNA sequence anchored FISH banding probe set. J Histochem Cytochem. 2008 May;56(5):487-93.
Liehr T, Starke H, Heller A, Kosyakova N, Mrasek K, Gross M, Karst C, Steinhaeuser U, Hunstig F, Fickelscher I, Kuechler A, Trifonov V, Romanenko SA, Weise A. Multicolor fluorescence in situ hybridization (FISH) applied to FISH-banding. Cytogenet Genome Res. 2006;114(3-4):240-4.
Gross M, Starke H, Trifonov V, Claussen U, Liehr T, Weise A. A molecular cytogenetic study of chromosome evolution in chimpanzee. Cytogenet Genome Res. 2006;112(1-2):67-75.
Trifonov V, Karst C, Claussen U, Mrasek K, Michel S, Avner P, Liehr T. Microdissection-derived murine mcb probes from somatic cell hybrids. J Histochem Cytochem. 2005 Jun;53(6):791-2.
Nietzel A, Rocchi M, Starke H, Heller A, Fiedler W, Wlodarska I, Loncarevic IF, Beensen V, Claussen U, Liehr T.
A new multicolor-FISH approach for the characterization of marker chromosomes: centromere-specific multicolor-FISH (cenM-FISH). Hum Genet. 2001 Mar;108(3):199-204.

best regards

Thomas Liehr, Institute of Human Genetics Jena, Germany