PDA

View Full Version : Peptide chemist, Fluorescence, DNA binding agents.


eugenio.vazquez
Aug 17, 10, 17:07
Dr. M. Eugenio Vázquez Sentís – CURRICULUM VITAE

We are interested in multidisciplinary collaborations with biology groups to exploit our synthetic expertise in the development of specific probes and tools applied to the study of specific protein-protein (and particularly phosphorylation-dependent interactions) and protein-DNA recognition.

Our research is characterized by a multi-disciplinary problem-solving approach including organic synthesis, spectroscopy and computational chemistry, applied to expand the available chemical tools for the study of complex molecular processes.

Please do not hesitate to contact for further information and research proposals


Contact Info

Name: M. Eugenio Vázquez Sentís
Born: September 20, 1973
Nationality: Spanish.

Address: Dept. de Química Orgánica - Fac. Quimica
Avda. de las Ciencias SN, Campus Sur
Universidad de Santiago de Compostela
15782 Santiago de Compostela
SPAIN
Webpage: usc.es/chembiousc/index.html
e-mail: eugenio.vazquez [at] usc.es
Phone: +34 881 814 346
Fax: +34 981 595 012


Education

PhD 3/2001 Univ. Santiago de Compostela (Spain) Organic Chemistry
Master 11/1996 Univ. de Santiago de Compostela (Spain) Organic Chemistry


Publications (last 5 years)

Vázquez, O.; Sánchez, M.I.; Martínez–Costas, J.; Vázquez, M.E.; Mascareñas, J.L. dsDNA-triggered energy transfer and lanthanide sensitization processes. Luminescent probing of specific A/T sequences.
Chem. Commun. 2010, 46, 5518–5520

Vázquez, O.; Sánchez, M.I.; Martínez–Costas, J.; Vázquez, M.E.; Mascareñas, J.L. Bis-aminobenzamidines: Versatile, Fluorogenic A/T-selective dsDNA Binders.
Org. Lett. 2010, 12, 216–219.

Vázquez López, M.; Vázquez, M.E.; Martínez-Calvo, M.; Pedrido, R.M.; Taglietti, A.; Bermejo, M.R. Sulfonamide-imines as selective fluorescent chemosensors for fluoride anion.
Org. Biomol. Chem. 2010, 8, 357–362.

Pazos, E.; Vázquez, O.; Mascareñas, J.L.; Vázquez, M.E. Peptide-based Fluorescent Biosensors.
Chem. Soc. Rev. 2009, 38, 3348–3359.

Vázquez, O.; Blanco, J.B.; Vázquez, M.E.; Martínez–Costas, J.; Castedo, L.; Mascareñas, J.L. Efficient DNA Binding and Nuclear Uptake by Distamycin Derivatives Conjugated to Octaarginine Sequences.
ChemBioChem 2008, 8, 2822–2829.

Vázquez-López, M.; Vázquez, M.E.; Gómez-Reino, C.; Pedrido, R.; Bermejo, M.R. A metallo-supramolecular approach to a half-subtractor.
New J. Chem. 2008, 32, 1473−1477.

Pazos, E.; Torrecilla, D.; Vázquez-López, M.; Castedo, L.; Mascareñas, J.L.; Vidal, A.; Vázquez, M.E. Cyclin A Probes by Means of Intermolecular Sensitization of Terbium-Chelating Peptides.
J. Am. Chem. Soc. 2008, 130, 9652−9653.

Vázquez, O.; Vázquez,M.E.; Blanco, J.B.; Castedo, L.; Mascareñas, J.L. Specific DNA Recognition by a Synthetic, Monomeric Cys2−His2 Zinc Finger Peptide Conjugated to a Minor Groove Binder.
Angew. Chem. Int. Ed. 2007, 46, 6886−6889.

Brea, R.J.; Vázquez, M.E.; Mosquera, M.; Castedo, L.; Granja, J.R. Controlling Multiple Fluorescent Signal Output in Cyclic Peptide–Based Supramolecular Systems.
J. Am. Chem. Soc. 2007, 129, 1653–1657.

Blanco, J.B.; Dodero, V.; Vázquez, M.E.; Mosquera, M.; Castedo, L.; Mascareñas, J.L. Sequence-specific DNA Binding by Non-covalent Peptide-Tripyrrole Conjugates.
Angew. Chem. Int. Ed. 2006, 118, 8390–8394.

Vazquez, M.E.; Blanco, J.B.; Salvadori, S.; Trapella, C.; Argazzi, R.; Bryant, S.D.; Jinsmaa, Y.; Lazarus, L.H.; Negri, L.; Giannini, E.; Lattanzi, R.; Colucci, M.; Balboni, G. 6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in δ- and µ-Selective Opioid Peptides.
J. Med. Chem. 2006, 49, 3653-3658.

Humphrey, D.*; Raijfur, Z.*; Vázquez, M.E.*; Scheswohl, D.; Schaller, M.; Jacobson, K.; Imperiali, B. *SAME CONTRIBUTION. in situ photoactivation of caged phosphotyrosine peptide derived from FAK temporarily halts lamellar extension of single migrating tumor cells.
J. Biol. Chem. 2005, 280, 22091–22101.

Vázquez, M.E.; Blanco, J.B.; Imperiali, B. Photophysics and Biological Applications of the Environment–Sensitive Fluorophore 6–N,N–Dimethyl-amino–2,3–naphthalimide.
J. Am. Chem. Soc. 2005, 127, 1300–1306.

Rothman, D.M.; Petersson, E. J.; Vázquez, M.E.; Brandt, G.S.; Dougherty, D.A.; Imperiali, B. Caged Phosphoproteins.
J. Am. Chem. Soc. 2005, 127, 846–847.


Research experience

1/07/2008-30/9/2008, Massachusetts Institute of Technology (Cambridge, USA), postdoctoral associate, bioorganic chemistry (Prof. Barbara Imperiali).

1/10/2001-30/9/2004, Massachusetts Institute of Technology (Cambridge, USA), postdoctoral fellow, bioorganic chemistry (Prof. Barbara Imperiali).

2004-2010. “Ramón y Cajal” researcher at the Organic Chemistry Department, University of Santiago de Compostela (Spain).

10/10/1998-11/12/1998. Department of Biochemistry, University of Barcelona (Barcelona, Spain), visiting scientist, computational chemistry (Prof. Modesto Orozco Lopez).

1/7/1997-11/12/1997. Department of Chemistry University of Cambridge (Cambridge, UK), visiting scientist, protein folding (Prof. Alan Ferscht).

8/7/1996-13/9/1996. R&D Department of the Procter & Gamble European Technical Center (Brussels, Belgium), optimization of rheological properties of liquid detergents. (Dr. Regine Labeque).


Honors

Lilly spanish young research award, 2010

National Young Researcher award by the Spanish Royal Society of Chemistry, 2008.

Third National Spanish Extraordinary Academic Achievement Award for Chemistry, Spain, 1997.

First Extraordinary Award of the Galician Government for Chemistry Degree Studies, Spain, 1997.